Research in medical dermo-cosmetics and dermatology
The research conducted by Matriscience is based on the exploration of the dermo-epidermal interaction, also known as cross-talk. It aims at determining in vitro the nature of the relationship between keratinocytes and human fibroblasts using the conditioned medium transfer during the processes of skin healing and repair.
The skin on the front line of defense against external stresses
The skin works as a crucial barrier and is the front line of defense
against environmental stresses of a mechanical, thermal, chemical or infectious nature, as well as against radiations.
The homeostasic stability of this tissular boundary between the external and internal environments is critical and depends on the quality of the dermo-epidermal interactions. Indeed, there is a constant metabolic dialogue between the keratinocyte epithelium of the epidermal layer on the surface, derived from the ectoderm, and the connective matrix which constitutes the dermis underneath, derived from the mesenchyme.
Beside this essential function, the skin also plays a communicative role through a sensory system which is able to send highly complex messages, the quality of which largely depends on the integrity of this multi-stratified epithelium on the surface, which can be adjusted by the application of dermo-cosmetic health treatments.
The homeostasic stability of this tissular boundary between the external and internal environments is critical and depends on the quality of the dermo-epidermal interactions. Indeed, there is a constant metabolic dialogue between the keratinocyte epithelium of the epidermal layer on the surface, derived from the ectoderm, and the connective matrix which constitutes the dermis underneath, derived from the mesenchyme.
Beside this essential function, the skin also plays a communicative role through a sensory system which is able to send highly complex messages, the quality of which largely depends on the integrity of this multi-stratified epithelium on the surface, which can be adjusted by the application of dermo-cosmetic health treatments.
The interaction between keratinocytes and fibroblasts, also known as cross-talk, lies at the center of our research at Matriscience
Matriscience has set up an original in vitro
platform
which makes it possible to study the messages exchanged between keratinocytes and fibroblasts, so as to then analyze and quantify the biological phenomena associated with the synthesis of components of the extracellular matrix, such as collagen, proteoglycans, fibronectin, laminin, elastin, etc.
This has led Matriscience to start exploring the theoretical secretome of keratinocytes and fibroblasts in order to characterize the messages resulting from various situations relating to age, environment, irradiation conditions (normal or accidental) and infectious dermatological diseases.
The objective is to transpose the molecular meaning of the message to the screening of new active principles that are likely to have an effect on the neosynthesis of proteins of interest at the heart of the dermo-epidermal interaction. These active principles are drug candidates in the field of dermatology and could be used in the treatment of psoriasis and dermatitis, as well as to improve skin repair and healing in chronic ulcers. They could also be used in the field of medical dermo-cosmetics in treatments for skin ageing, cutaneous lesions caused by juvenile acne or keloid and hypertrophic scars.
This has led Matriscience to start exploring the theoretical secretome of keratinocytes and fibroblasts in order to characterize the messages resulting from various situations relating to age, environment, irradiation conditions (normal or accidental) and infectious dermatological diseases.
The objective is to transpose the molecular meaning of the message to the screening of new active principles that are likely to have an effect on the neosynthesis of proteins of interest at the heart of the dermo-epidermal interaction. These active principles are drug candidates in the field of dermatology and could be used in the treatment of psoriasis and dermatitis, as well as to improve skin repair and healing in chronic ulcers. They could also be used in the field of medical dermo-cosmetics in treatments for skin ageing, cutaneous lesions caused by juvenile acne or keloid and hypertrophic scars.